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Cryo-EM SPA datasets for Antibodies 12-16 & 12-19 in complex with prefusion SARS-CoV-2 Spike glycoprotein (K3 movies/.tif files)

ABSTRACT:

SUBMITTER: Ryan Gavin Casner

PROVIDER: EMPIAR-11335 | biostudies-other |

REPOSITORIES: biostudies-other

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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.

Liu Lihong L Casner Ryan G RG Guo Yicheng Y Wang Qian Q Iketani Sho S Chan Jasper Fuk-Woo JF Yu Jian J Dadonaite Bernadeta B Nair Manoj S MS Mohri Hiroshi H Reddem Eswar R ER Yuan Shuofeng S Poon Vincent Kwok-Man VK Chan Chris Chung-Sing CC Yuen Kwok-Yung KY Sheng Zizhang Z Huang Yaoxing Y Bloom Jesse D JD Shapiro Lawrence L Ho David D DD

Immunity 20230929 10

SARS-CoV-2 continues to evolve, with many variants evading clinically authorized antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities against the virus, we screened serum samples from convalescing COVID-19 patients. We isolated two mAbs, 12-16 and 12-19, which neutralized all SARS-CoV-2 variants tested, including the XBB subvariants, and prevented infection in hamsters challenged with Omicron BA.1 intranasally. Structurally, both antibodies targeted a conserve ...[more]

PMID: 37776849

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