Ontology highlight
ABSTRACT:
SUBMITTER: Ryan Gavin Casner
PROVIDER: EMPIAR-11335 | biostudies-other |
REPOSITORIES: biostudies-other
Liu Lihong L Casner Ryan G RG Guo Yicheng Y Wang Qian Q Iketani Sho S Chan Jasper Fuk-Woo JF Yu Jian J Dadonaite Bernadeta B Nair Manoj S MS Mohri Hiroshi H Reddem Eswar R ER Yuan Shuofeng S Poon Vincent Kwok-Man VK Chan Chris Chung-Sing CC Yuen Kwok-Yung KY Sheng Zizhang Z Huang Yaoxing Y Bloom Jesse D JD Shapiro Lawrence L Ho David D DD
Immunity 20230929 10
SARS-CoV-2 continues to evolve, with many variants evading clinically authorized antibodies. To isolate monoclonal antibodies (mAbs) with broadly neutralizing capacities against the virus, we screened serum samples from convalescing COVID-19 patients. We isolated two mAbs, 12-16 and 12-19, which neutralized all SARS-CoV-2 variants tested, including the XBB subvariants, and prevented infection in hamsters challenged with Omicron BA.1 intranasally. Structurally, both antibodies targeted a conserve ...[more]