Dataset Information
2.3 A structure of the ATP-dependent chromatin remodeler Chd1 bound to the nucleosome in a nucleotide-free state
Ontology highlight
ABSTRACT:
SUBMITTER: Jean-Paul Armache
PROVIDER: EMPIAR-10876 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state.
Nature structural & molecular biology 20220216 2
Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a nucleosome in a nucleotide-free state, determined by cryo-EM to 2.3 Å resolution. The remodeler stimulates the nucleosome to absorb an additional nucleotide on each strand at two different locations: on the tracking strand within the ATPase binding site and on the guide strand one helical turn from the ATPase motor. Remarkably, the ad ...[more]