Dataset Information
Cryo-EM micrographs of GABA(A)Rs purified from cells expressing human full-length alpha4, beta3 and delta subunits, in presence of THIP (gaboxadol), histamine and nanobody Nb25
Ontology highlight
ABSTRACT:
SUBMITTER: Andrija Sente
PROVIDER: EMPIAR-10910 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Differential assembly diversifies GABA<sub>A</sub> receptor structures and signalling.
Nature 20220330 7904
Type A γ-aminobutyric acid receptors (GABA<sub>A</sub>Rs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits<sup>1,2</sup> and can be modulated by essential medicines including general anaesthetics and benzodiazepines<sup>3</sup>. Human GABA<sub>A</sub>R subunits are encoded by 19 paralogous genes that can, in theory, give rise to 495,235 receptor types. However, the principles that govern the formation of pentamers, the permutational landsca ...[more]