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Cryo-EM micrographs of GABA(A)Rs purified from cells expressing human full-length alpha4, beta3 and delta subunits, in presence of GABA, histamine and nanobody Nb25


ABSTRACT:

SUBMITTER: Andrija Sente 

PROVIDER: EMPIAR-10914 | biostudies-other |

REPOSITORIES: biostudies-other

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Type A γ-aminobutyric acid receptors (GABA<sub>A</sub>Rs) are pentameric ligand-gated chloride channels that mediate fast inhibitory signalling in neural circuits<sup>1,2</sup> and can be modulated by essential medicines including general anaesthetics and benzodiazepines<sup>3</sup>. Human GABA<sub>A</sub>R subunits are encoded by 19 paralogous genes that can, in theory, give rise to 495,235 receptor types. However, the principles that govern the formation of pentamers, the permutational landsca  ...[more]

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