Dataset Information
CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate
Ontology highlight
ABSTRACT:
SUBMITTER: Georgios Skiniotis
PROVIDER: EMPIAR-10978 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
G-protein activation by a metabotropic glutamate receptor.
Nature 20210630 7867
Family C G-protein-coupled receptors (GPCRs) operate as obligate dimers with extracellular domains that recognize small ligands, leading to G-protein activation on the transmembrane (TM) domains of these receptors by an unknown mechanism<sup>1</sup>. Here we show structures of homodimers of the family C metabotropic glutamate receptor 2 (mGlu2) in distinct functional states and in complex with heterotrimeric G<sub>i</sub>. Upon activation of the extracellular domain, the two transmembrane domain ...[more]