Dataset Information
Nudaurelia capensis omega virus maturation intermediates captured at pH5.6 (insect cell expressed VLPs)
Ontology highlight
ABSTRACT:
SUBMITTER: David Mark Lawson
PROVIDER: EMPIAR-11083 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Unraveling the maturation pathway of a eukaryotic virus through cryo-EM.
Proceedings of the National Academy of Sciences of the United States of America 20260225 9
Virus maturation is a fundamental biological process involving large-scale structural reorganizations that drive functional activation and lead to infectivity. Understanding the steps from the initial procapsid assembly to mature virions is essential, both for comprehending viral life cycles and for developing antiviral therapies. However, capturing these steps has been challenging due to the transient and elusive nature of intermediate states. The nonenveloped, T = 4, ssRNA-containing, <i>Nudau ...[more]