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Cryo-ET tilt series of HPIV3 clinical isolates


ABSTRACT:

SUBMITTER: Tara Charlie Marcink 

PROVIDER: EMPIAR-11103 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications


Paramyxoviruses-including important pathogens like parainfluenza, measles, and Nipah viruses-use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use cryo-electron tomography to visualize the fusion complex of human parainfluenza virus 3 (HN/F) on the surface of authentic clinical viruses at a subnanometer resolution sufficient to answer mechanistic questions. An HN loop inserts in a pocket on F, sho  ...[more]

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