Dataset Information
Cryo-ET tilt series of HPIV3 clinical isolates in the presence of an F neutralizing Fab
Ontology highlight
ABSTRACT:
SUBMITTER: Tara Charlie Marcink
PROVIDER: EMPIAR-11104 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms.
Science advances 20230210 6
Paramyxoviruses-including important pathogens like parainfluenza, measles, and Nipah viruses-use a receptor binding protein [hemagglutinin-neuraminidase (HN) for parainfluenza] and a fusion protein (F), acting in a complex, to enter cells. We use cryo-electron tomography to visualize the fusion complex of human parainfluenza virus 3 (HN/F) on the surface of authentic clinical viruses at a subnanometer resolution sufficient to answer mechanistic questions. An HN loop inserts in a pocket on F, sho ...[more]