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Single-Particle Cryo-EM of AAV2 at Various Tilts


ABSTRACT:

SUBMITTER: Yong Zi Tan 

PROVIDER: EMPIAR-11791 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural biology efforts using cryogenic electron microscopy are frequently stifled by specimens adopting "preferred orientations" on grids, leading to anisotropic map resolution and impeding structure determination. Tilting the specimen stage during data collection is a generalizable solution but has historically led to substantial resolution attenuation. Here, we develop updated data collection and image processing workflows and demonstrate, using multiple specimens, that resolution attenuat  ...[more]

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