Dataset Information
Cryo-EM micrographs of anti-CRISPR associated protein Aca2 bound to its RNA
Ontology highlight
ABSTRACT:
SUBMITTER: Max Wilkinson
PROVIDER: EMPIAR-11918 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.
Nature 20240710 8021
In all organisms, regulation of gene expression must be adjusted to meet cellular requirements and frequently involves helix-turn-helix (HTH) domain proteins<sup>1</sup>. For instance, in the arms race between bacteria and bacteriophages, rapid expression of phage anti-CRISPR (acr) genes upon infection enables evasion from CRISPR-Cas defence; transcription is then repressed by an HTH-domain-containing anti-CRISPR-associated (Aca) protein, probably to reduce fitness costs from excessive expressio ...[more]