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Conjugated polymer-based fluorescence turn-on sensor for nitric oxide.

ABSTRACT: A turn-on fluorescent sensor for NO (g) in solution was synthesized using a bipyridyl-substituted poly(p-phenylene vinylene) derivative (CP1) as the sensory scaffold. The action of NO (g) upon the CP1-Cu(II) complex reduces it to the CP1-Cu(I) complex with a concomitant 2.8-fold increase in emission intensity. The reagent is selective for NO (g) versus other biological reactive nitrogen species, except for nitroxyl, and has a detection sensitivity limit of 6.3 nM. [structure: see text]

SUBMITTER: Smith RC

PROVIDER: S-EPMC1352166 | biostudies-other | 2005 Aug

REPOSITORIES: biostudies-other

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Conjugated polymer-based fluorescence turn-on sensor for nitric oxide.

Smith Rhett C RC Tennyson Andrew G AG Lim Mi Hee MH Lippard Stephen J SJ

Organic letters 20050801 16

A turn-on fluorescent sensor for NO (g) in solution was synthesized using a bipyridyl-substituted poly(p-phenylene vinylene) derivative (CP1) as the sensory scaffold. The action of NO (g) upon the CP1-Cu(II) complex reduces it to the CP1-Cu(I) complex with a concomitant 2.8-fold increase in emission intensity. The reagent is selective for NO (g) versus other biological reactive nitrogen species, except for nitroxyl, and has a detection sensitivity limit of 6.3 nM. [structure: see text] ...[more]

PMID: 16048345

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