Ontology highlight
ABSTRACT:
SUBMITTER: Parone PA
PROVIDER: S-EPMC1636857 | biostudies-other | 2006 Oct
REPOSITORIES: biostudies-other
Molecular and cellular biology 20061001 20
Apoptosis, induced by a number of death stimuli, is associated with a fragmentation of the mitochondrial network. These morphological changes in mitochondria have been shown to require proteins, such as Drp1 or hFis1, which are involved in regulating the fission of mitochondria. However, the precise role of mitochondrial fission during apoptosis remains elusive. Here we report that inhibiting the fission machinery in Bax/Bak-mediated apoptosis, by down-regulating of Drp1 or hFis1, prevents the f ...[more]