Ontology highlight
ABSTRACT:
SUBMITTER: Yi CH
PROVIDER: S-EPMC2080898 | biostudies-other | 2007 Nov
REPOSITORIES: biostudies-other
Yi Caroline H CH Sogah Dodzie K DK Boyce Michael M Degterev Alexei A Christofferson Dana E DE Yuan Junying J
The Journal of cell biology 20071112 4
Apoptosis is an evolutionally conserved cellular suicide mechanism that can be activated in response to a variety of stressful stimuli. Increasing evidence suggests that apoptotic regulation relies on specialized cell death signaling pathways and also integrates diverse signals from additional regulatory circuits, including those of cellular homeostasis. We present a genome-wide RNA interference screen to systematically identify regulators of apoptosis induced by DNA damage in Drosophila melanog ...[more]