Ontology highlight
ABSTRACT:
SUBMITTER: Mattapallil JJ
PROVIDER: S-EPMC2118314 | biostudies-other | 2006 Jun
REPOSITORIES: biostudies-other
Mattapallil Joseph J JJ Douek Daniel C DC Buckler-White Alicia A Montefiori David D Letvin Norman L NL Nabel Gary J GJ Roederer Mario M
The Journal of experimental medicine 20060530 6
Acute simian immunodeficiency virus (SIV)/human immunodeficiency virus infection is accompanied by a massive destruction of CD4 memory T cells across all the tissue compartments. These early events set the course toward disease progression and immunodeficiency. Here, we demonstrate that prior vaccination reduces this destruction during acute SIV Mac251 infection, leading to better survival and long-term outcome. Systemic vaccination with a DNA-prime recombinant adenovirus boost regimen preserved ...[more]