Ontology highlight
ABSTRACT:
SUBMITTER: Park L
PROVIDER: S-EPMC2234141 | biostudies-other | 2008 Jan
REPOSITORIES: biostudies-other
Park Laibaik L Zhou Ping P Pitstick Rose R Capone Carmen C Anrather Josef J Norris Erin H EH Younkin Linda L Younkin Steven S Carlson George G McEwen Bruce S BS Iadecola Costantino C
Proceedings of the National Academy of Sciences of the United States of America 20080117 4
Alterations in cerebrovascular regulation related to vascular oxidative stress have been implicated in the mechanisms of Alzheimer's disease (AD), but their role in the amyloid deposition and cognitive impairment associated with AD remains unclear. We used mice overexpressing the Swedish mutation of the amyloid precursor protein (Tg2576) as a model of AD to examine the role of reactive oxygen species produced by NADPH oxidase in the cerebrovascular alterations, amyloid deposition, and behavioral ...[more]