Ontology highlight
ABSTRACT:
SUBMITTER: Cormier JH
PROVIDER: S-EPMC2740909 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Cormier James H JH Tamura Taku T Sunryd Johan C JC Hebert Daniel N DN
Molecular cell 20090601 5
Terminally misfolded or unassembled secretory proteins are retained in the endoplasmic reticulum (ER) and subsequently cleared by the ER-associated degradation (ERAD) pathway. The degradation of ERAD substrates involves mannose trimming of N-linked glycans; however, the mechanisms of substrate recognition and sorting to the ERAD pathway are poorly defined. EDEM1 (ER degradation-enhancing alpha-mannosidase-like 1 protein) has been proposed to play a role in ERAD substrate signaling or recognition ...[more]