Ontology highlight
ABSTRACT:
SUBMITTER: Hu L
PROVIDER: S-EPMC2753727 | biostudies-other | 2009 Oct
REPOSITORIES: biostudies-other
Virology 20090826 1
Human papillomavirus (HPV) is a non-enveloped DNA virus with an approximately 8000 base pair genome. Infection with certain types of HPV is associated with cervical cancer, although the molecular mechanism by which HPV induces carcinogenesis is poorly understood. Three genes encoded by HPV16 are regarded as oncogenic - E5, E6, and E7. The role of E5 has been controversial. Expression of HPV16 E5 causes cell-cell fusion, an event that can lead to increased chromosomal instability, particularly in ...[more]