Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC3186058 | biostudies-other | 2010 Sep
REPOSITORIES: biostudies-other
Publications
Alpha-synuclein in alpha-helical conformation at air-water interface: implication of conformation and orientation changes during its accumulation/aggregation.
Wang Chengshan C Shah Nilam N Thakur Garima G Zhou Feimeng F Leblanc Roger M RM
Chemical communications (Cambridge, England) 20100816 36
Alpha-synuclein, a natively unstructured protein important in the neuropathology of Parkinson's disease, was found to form a Langmuir monolayer in an alpha-helical conformation with its helical axis parallel to the air-water interface. This study sheds light on the role of vesicles in neuronal cells in the accumulation/aggregation of alpha-synuclein. ...[more]
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