Ontology highlight
ABSTRACT:
SUBMITTER: Chapman HA
PROVIDER: S-EPMC3223845 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Chapman Harold A HA Li Xiaopeng X Alexander Jonathan P JP Brumwell Alexis A Lorizio Walter W Tan Kevin K Sonnenberg Arnoud A Wei Ying Y Vu Thiennu H TH
The Journal of clinical investigation 20110623 7
Laminins and their integrin receptors are implicated in epithelial cell differentiation and progenitor cell maintenance. We report here that a previously unrecognized subpopulation of mouse alveolar epithelial cells (AECs) expressing the laminin receptor α6β4, but little or no pro-surfactant C (pro-SPC), is endowed with regenerative potential. Ex vivo, this subpopulation expanded clonally as progenitors but also differentiated toward mature cell types. Integrin β4 itself was not required for AEC ...[more]