Ontology highlight
ABSTRACT:
SUBMITTER: Vogel R
PROVIDER: S-EPMC3255894 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Vogel Rebecca R Seyffert Michael M Strasser Regina R de Oliveira Anna P AP Dresch Christiane C Glauser Daniel L DL Jolinon Nelly N Salvetti Anna A Weitzman Matthew D MD Ackermann Mathias M Fraefel Cornel C
Journal of virology 20111019 1
Adeno-associated virus type 2 (AAV2) is a human parvovirus that relies on a helper virus for efficient replication. Herpes simplex virus 1 (HSV-1) supplies helper functions and changes the environment of the cell to promote AAV2 replication. In this study, we examined the accumulation of cellular replication and repair proteins at viral replication compartments (RCs) and the influence of replicating AAV2 on HSV-1-induced DNA damage responses (DDR). We observed that the ATM kinase was activated i ...[more]