Ontology highlight
ABSTRACT:
SUBMITTER: Bleuyard JY
PROVIDER: S-EPMC3271335 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
EMBO reports 20120201 2
The partner and localizer of breast cancer 2 susceptibility protein (PALB2) is crucial for the repair of DNA damage by homologous recombination. Here, we report that chromatin-association motif (ChAM), an evolutionarily conserved motif in PALB2, is necessary and sufficient to mediate its chromatin association in both unperturbed and damaged cells. ChAM is distinct from the previously described PALB2 DNA-binding regions. Deletion of ChAM decreases PALB2 and Rad51 accumulation at DNA damage sites ...[more]