Ontology highlight
ABSTRACT:
SUBMITTER: Meijer D
PROVIDER: S-EPMC332873 | biostudies-other | 1990 Dec
REPOSITORIES: biostudies-other
Meijer D D Graus A A Kraay R R Langeveld A A Mulder M P MP Grosveld G G
Nucleic acids research 19901201 24
We have cloned a cDNA encoding a novel octamer binding factor Oct6 that is expressed in undifferentiated ES cells. Expression of the Oct6 gene is downregulated upon differentiation of these cells by aggregate formation. Furthermore the gene is transiently up regulated during retinoic acid induced differentiation of P19 EC cells, reaching maximum levels of expression one day after RA addition. Sequence analysis of the cDNA encoding the Oct6 protein indicated that the Oct6 gene is a member of the ...[more]