Ontology highlight
ABSTRACT:
SUBMITTER: Shelke SA
PROVIDER: S-EPMC3333849 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Shelke Sandip A SA Sigurdsson Snorri Th ST
Nucleic acids research 20111230 8
The influence of structural changes of an abasic site in duplex DNA on noncovalent and site-directed spin labeling (NC-SDSL) of the spin label ç were examined with electron paramagnetic resonance (EPR) spectroscopy. The binding affinities of ç to sixteen different DNA duplexes containing all possible sequences immediately flanking the abasic site were determined and the results showed that the binding of ç is highly flanking-sequence dependent. In general, a 5'-dG nucleotide favors the binding o ...[more]