Ontology highlight
ABSTRACT:
SUBMITTER: Pepe G
PROVIDER: S-EPMC335044 | biostudies-other | 1989 Nov
REPOSITORIES: biostudies-other
Pepe G G Gadaleta G G Palazzo G G Saccone C C
Nucleic acids research 19891101 21
Theoretical analysis and experimental approaches by gel electrophoresis in retarding conditions allowed us to identify the presence of an intrinsic bending in the D-loop containing region of the rat mitochondrial genome. The curvature was located in the right domain of the sequence analyzed, between the origin of replication of the heavy strand and its promoter. The preliminary evidence of a specific recognition of the bent DNA with mitochondrial matrix proteins suggests a probable role of this ...[more]