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Contrast enhanced high-resolution diffuse optical tomography of the human brain using ICG.


ABSTRACT: Non-invasive diffuse optical tomography (DOT) of the adult brain has recently been shown to improve the spatial resolution for functional brain imaging applications. Here we show that high-resolution (HR) DOT is also advantageous for clinical perfusion imaging using an optical contrast agent. We present the first HR-DOT results with a continuous wave near infrared spectroscopy setup using a dense grid of optical fibers and indocyanine green (ICG) as an exogenic contrast agent. We find an early arrival of the ICG bolus in the intracerebral tissue and a delayed arrival of the bolus in the extracerebral tissue, achieving the separation of both layers. This demonstrates the method's potential for brain perfusion monitoring in neurointensive care patients.

SUBMITTER: Habermehl C 

PROVIDER: S-EPMC3482886 | biostudies-other | 2011 Sep

REPOSITORIES: biostudies-other

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