Ontology highlight
ABSTRACT:
SUBMITTER: Fox CB
PROVIDER: S-EPMC3485880 | biostudies-other | 2012 Oct
REPOSITORIES: biostudies-other
Clinical and vaccine immunology : CVI 20120815 10
New malaria vaccines are urgently needed to improve vaccine protective efficacy. PfCelTOS is a recombinant malaria vaccine antigen that has shown protective efficacy in a small-animal challenge model when combined with a water-in-oil emulsion adjuvant (Montanide ISA 720). In this report, we show that PfCelTOS vaccines containing GLA-SE (a stable oil-in-water emulsion combined with a Toll-like receptor 4 [TLR4] agonist) elicit strong Th1-type immune responses in BALB/c mice. These responses inclu ...[more]