Ontology highlight
ABSTRACT:
SUBMITTER: Arteaga-Solis E
PROVIDER: S-EPMC3815545 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Arteaga-Solis Emilio E Zee Tiffany T Emala Charles W CW Vinson Charles C Wess Jürgen J Karsenty Gerard G
Cell metabolism 20130101 1
Impaired lung function caused by decreased airway diameter (bronchoconstriction) is frequently observed whether body weight is abnormally high or low. That these opposite conditions affect the airways similarly suggests that the regulation of airway diameter and body weight are intertwined. We show here that, independently of its regulation of appetite, melanocortin pathway, or sympathetic tone, leptin is necessary and sufficient to increase airway diameter by signaling through its cognate recep ...[more]