Ontology highlight
ABSTRACT:
SUBMITTER: Prosser GA
PROVIDER: S-EPMC3944805 | biostudies-other | 2013 Oct
REPOSITORIES: biostudies-other
Prosser Gareth A GA de Carvalho Luiz Pedro S LP
Biochemistry 20130925 40
d-Cycloserine is a second-line drug approved for use in the treatment of patients infected with Mycobacterium tuberculosis, the etiologic agent of tuberculosis. The unique mechanism of action of d-cycloserine, compared with those of other clinically employed antimycobacterial agents, represents an untapped and exploitable resource for future rational drug design programs. Here, we show that d-cycloserine is a slow-onset inhibitor of MtDdl and that this behavior is specific to the M. tuberculosis ...[more]