Ontology highlight
ABSTRACT:
SUBMITTER: Ronaghi M
PROVIDER: S-EPMC4028088 | biostudies-other | 2014 Jun
REPOSITORIES: biostudies-other
Ronaghi Mohammad M Nasr Marjan M Ealy Megan M Durruthy-Durruthy Robert R Waldhaus Joerg J Diaz Giovanni H GH Joubert Lydia-Marie LM Oshima Kazuo K Heller Stefan S
Stem cells and development 20140310 11
In mammals, the permanence of many forms of hearing loss is the result of the inner ear's inability to replace lost sensory hair cells. Here, we apply a differentiation strategy to guide human embryonic stem cells (hESCs) into cells of the otic lineage using chemically defined attached-substrate conditions. The generation of human otic progenitor cells was dependent on fibroblast growth factor (FGF) signaling, and protracted culture led to the upregulation of markers indicative of differentiated ...[more]