Therapeutic effect of Xue Niao An on glyoxylate-induced calcium oxalate crystal deposition based on urinary metabonomics approach.
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ABSTRACT:
SUBMITTER: Peng Z
PROVIDER: S-EPMC4227831 | biostudies-other | 2014 Nov
REPOSITORIES: biostudies-other
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Therapeutic effect of Xue Niao An on glyoxylate-induced calcium oxalate crystal deposition based on urinary metabonomics approach.
Peng Zhongjiang Z Chen Wei W Gao Songyan S Su Li L Li Na N Wang Li L Lou Ziyang Z Dong Xin X Guo Zhiyong Z
Journal of clinical biochemistry and nutrition 20141004 3
The anti-nephrolithiasis effect of Xue Niao An (XNA) capsules is explored by analyzing urine metabolic profiles in mouse models, with ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). An animal model of calcium oxalate crystal renal deposition was established in mice by intra-abdominal injection of glyoxylate. Then, treatment with XNA by intra-gastric administration was performed. At the end of the study, calcium deposition in kidney was me ...[more]
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