Ontology highlight
ABSTRACT:
SUBMITTER: Ditzel HJ
PROVIDER: S-EPMC43651 | biostudies-other | 1994 Apr
REPOSITORIES: biostudies-other
Ditzel H J HJ Barbas S M SM Barbas C F CF Burton D R DR
Proceedings of the National Academy of Sciences of the United States of America 19940401 9
Human immunodeficiency virus type 1 (HIV-1) seropositive donors typically have high serum antibody titers to a range of autoantigens, and the corresponding autoantibodies have been suggested to be of importance in the pathogenesis of HIV-1 infection. We have prepared 38 IgG human monoclonal autoantibodies from asymptomatic HIV-1 seropositive donors with elevated serum titers to autoantigens by construction of Fab combinatorial libraries on the surface of phage and affinity selection using a rang ...[more]