Ontology highlight
ABSTRACT:
SUBMITTER: McGrail DJ
PROVIDER: S-EPMC4601008 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
McGrail Daniel J DJ McAndrews Kathleen M KM Brandenburg Chandler P CP Ravikumar Nithin N Kieu Quang Minh N QM Dawson Michelle R MR
Biophysical journal 20151001 7
For a solid tumor to grow, it must be able to support the compressive stress that is generated as it presses against the surrounding tissue. Although the literature suggests a role for the cytoskeleton in counteracting these stresses, there has been no systematic evaluation of which filaments are responsible or to what degree. Here, using a three-dimensional spheroid model, we show that cytoskeletal filaments do not actively support compressive loads in breast, ovarian, and prostate cancer. Howe ...[more]