Ontology highlight
ABSTRACT:
SUBMITTER: Pu F
PROVIDER: S-EPMC4649707 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Scientific reports 20151118
Gastrin-releasing peptide receptor (GRPR) is differentially expressed on the surfaces of various diseased cells, including prostate and lung cancer. However, monitoring temporal and spatial expression of GRPR in vivo by clinical MRI is severely hampered by the lack of contrast agents with high relaxivity, targeting capability and tumor penetration. Here, we report the development of a GRPR-targeted MRI contrast agent by grafting the GRPR targeting moiety into a scaffold protein with a designed G ...[more]