Ontology highlight
ABSTRACT:
SUBMITTER: Adcock HV
PROVIDER: S-EPMC4832826 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20151030 51
Gold carbene reactivity patterns were accessed by ynamide insertion into a C(sp(3) )H bond. A substantial increase in molecular complexity occurred through the cascade polycyclization of N-allyl ynamides to form fused nitrogen-heterocycle scaffolds. Exquisite selectivity was observed despite several competing pathways in an efficient gold-catalyzed synthesis of densely functionalized C(sp(3) )-rich polycycles and a copper-catalyzed synthesis of fused pyridine derivatives. The respective gold-ke ...[more]