Ontology highlight
ABSTRACT:
SUBMITTER: Shu R
PROVIDER: S-EPMC4669786 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Shu R R Wong W W Ma Q H QH Yang Z Z ZZ Zhu H H Liu F J FJ Wang P P Ma J J Yan S S Polo J M JM Bernard C C A CC Stanton L W LW Dawe G S GS Xiao Z C ZC
Cell death & disease 20150219
Amyloid precursor protein (APP) is best known for its involvement in the pathogenesis of Alzheimer's disease. We have previously demonstrated that APP intracellular domain (AICD) regulates neurogenesis; however, the mechanisms underlying AICD-mediated regulation of neuronal differentiation are not yet fully characterized. Using genome-wide chromatin immunoprecipitation approaches, we found that AICD is specifically recruited to the regulatory regions of several microRNA genes, and acts as a tran ...[more]