Ontology highlight
ABSTRACT:
SUBMITTER: Mahavadi P
PROVIDER: S-EPMC4939895 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Mahavadi Poornima P Knudsen Lars L Venkatesan Shalini S Henneke Ingrid I Hegermann Jan J Wrede Christoph C Ochs Matthias M Ahuja Saket S Chillappagari Shashi S Ruppert Clemens C Seeger Werner W Korfei Martina M Guenther Andreas A
The journal of pathology. Clinical research 20150603 4
Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its antiarrhythmic properties. It exerts serious side-effects even in patients receiving low doses. AD is well-known to induce apoptosis of type II alveolar epithelial cells (AECII), a mechanism that has been suggested to play an important role in AD-induced lung fibrosis. The precise molecular mechanisms underlying this disease are, however, still unclear. Because of its amphiphilic nature, AD becomes enriched in the ly ...[more]