Ontology highlight
ABSTRACT:
SUBMITTER: Scott PJ
PROVIDER: S-EPMC4983726 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Scott Peter J H PJ Shao Xia X Desmond Timothy J TJ Hockley Brian G BG Sherman Phillip P Quesada Carole A CA Frey Kirk A KA Koeppe Robert A RA Kilbourn Michael R MR Bohnen Nicolaas I NI
ACS medicinal chemistry letters 20160601 8
Clarithromycin is a potential treatment for hypersomnia acting through proposed negative allosteric modulation of GABAA receptors. We were interested whether this therapeutic benefit might extend to Parkinson's disease (PD) patients because GABAergic neurotransmission is implicated in postural control. Prior to initiating clinical studies in PD patients, we wished to better understand clarithromycin's mechanism of action. In this work we investigated whether the proposed activity of clarithromyc ...[more]