Ontology highlight
ABSTRACT:
SUBMITTER: Szumilak M
PROVIDER: S-EPMC5037830 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Szumilak Marta M Merecz Anna A Strek Malgorzata M Stanczak Andrzej A Stanczak Andrzej A Inglot Tadeusz W TW Karwowski Boleslaw T BT
International journal of molecular sciences 20160919 9
The interaction of polyamine conjugates with DNA double helix has been studied. Binding properties were examined by ethidium bromide (EtBr) displacement and DNA unwinding/topoisomerase I/II (Topo I/II) activity assays, as well as dsDNA thermal stability studies and circular dichroism spectroscopy. Genotoxicity of the compounds was estimated by a comet assay. It has been shown that only compound <b>2a</b> can interact with dsDNA via an intercalative binding mode as it displaced EtBr from the dsDN ...[more]