Ontology highlight
ABSTRACT:
SUBMITTER: Smith CA
PROVIDER: S-EPMC5050023 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Smith Chris A CA McAinsh Andrew D AD Burroughs Nigel J NJ
eLife 20160903
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle - a dynamic microtubule-based force-generating machine. Connections to this spindle are mediated by sister kinetochore pairs, that form dynamic end-on attachments to microtubules emanating from opposite spindle poles. This bi-orientation generates forces that have been reported to stretch the kinetochore itself, which has been suggested to stabilise attachment and silence the spindle checkpoint. We revea ...[more]