Ontology highlight
ABSTRACT:
SUBMITTER: Lazaro S
PROVIDER: S-EPMC5354839 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Lázaro Sara S Pérez-Crespo Miriam M Enguita Ana Belén AB Hernández Pilar P Martínez-Palacio Jesús J Oteo Marta M Sage Julien J Paramio Jesús M JM Santos Mirentxu M
Oncotarget 20170101 3
Lung cancer is a deadly disease with increasing cases diagnosed worldwide and still a very poor prognosis. While mutations in the retinoblastoma (RB1) tumor suppressor have been reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate. To begin to investigate the role of these two Rb family proteins in lung tumorigenesis, we have generated a conditional triple knockout mouse model (TKO) in which the three ...[more]