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Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells.

ABSTRACT: Renal transplantation is the renal replacement modality of choice for suitable candidates with advanced CKD or ESRD. Prevention of rejection, however, requires treatment with nonspecific pharmacologic immunosuppressants that carry both systemic and nephrologic toxicities. Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden. Here, we review the immunologic underpinnings of Treg therapy and technical challenges to developing successful cell therapy. These issues include the selection of appropriate Treg subsets, ex vivo Treg expansion approaches, how many Tregs to administer and when, and how to care for patients after Treg administration.

SUBMITTER: Zwang NA

PROVIDER: S-EPMC5491296 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells.

Zwang Nicholas A NA Leventhal Joseph R JR

Journal of the American Society of Nephrology : JASN 20170502 7

Renal transplantation is the renal replacement modality of choice for suitable candidates with advanced CKD or ESRD. Prevention of rejection, however, requires treatment with nonspecific pharmacologic immunosuppressants that carry both systemic and nephrologic toxicities. Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden. Here, we review the immunologic underpinnings of Treg therapy and technical challenges to developing succes ...[more]

PMID: 28465379

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