Ontology highlight
ABSTRACT:
SUBMITTER: Zwang NA
PROVIDER: S-EPMC5491296 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Journal of the American Society of Nephrology : JASN 20170502 7
Renal transplantation is the renal replacement modality of choice for suitable candidates with advanced CKD or ESRD. Prevention of rejection, however, requires treatment with nonspecific pharmacologic immunosuppressants that carry both systemic and nephrologic toxicities. Use of a patient's own suppressive regulatory T cells (Tregs) is an attractive biologic approach to reduce this burden. Here, we review the immunologic underpinnings of Treg therapy and technical challenges to developing succes ...[more]