Ontology highlight
ABSTRACT:
SUBMITTER: Huang YC
PROVIDER: S-EPMC5609907 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Huang Yin-Cheng YC Lin Sheng-Jia SJ Shih Hung-Yu HY Chou Chung-Han CH Chu Hsiao-Han HH Chiu Ching-Chi CC Yuh Chiou-Hwa CH Yeh Tu-Hsueh TH Cheng Yi-Chuan YC
Oncotarget 20170627 38
Glioblastomas are among the most fatal brain tumors; however, the molecular determinants of their tumorigenic behavior are not adequately defined. In this study, we analyzed the role of KMT2A in the glioblastoma cell line U-87 MG. KMT2A knockdown promoted cell proliferation. Moreover, it increased the DNA methylation of <i>NOTCH1</i> and <i>NOTCH3</i> and reduced the expression of <i>NOTCH1</i> and <i>NOTCH3</i>. NOTCH1 or NOTCH3 activation inhibited U-87 MG cell proliferation, whereas NOTCH1 an ...[more]