Ontology highlight
ABSTRACT:
SUBMITTER: Perrier V
PROVIDER: S-EPMC5625119 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Perrier Véronique V Imberdis Thibaud T Lafon Pierre-André PA Cefis Marina M Wang Yunyun Y Huetter Elisabeth E Arnaud Jacques-Damien JD Alvarez-Martinez Teresa T Le Guern Naig N Maquart Guillaume G Lagrost Laurent L Desrumaux Catherine C
Journal of lipid research 20170801 10
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases with an urgent need for therapeutic and prophylactic strategies. At the time when the blood-mediated transmission of prions was demonstrated, in vitro studies indicated a high binding affinity of the scrapie prion protein (PrP<sup>Sc</sup>) with apoB-containing lipoproteins, i.e., the main carriers of cholesterol in human blood. The aim of the present study was to explore the relationship between circulating cholester ...[more]