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Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics.

ABSTRACT: Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a ?-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylamino functionalities attached to the BODIPY core. The on/off emission of the fluorescent CNOs is fast and reversible both in solution and in vitro, making this nanomaterial suitable as pH-dependent probes for diagnostic applications.

SUBMITTER: Lettieri S

PROVIDER: S-EPMC5629398 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics.

Lettieri Stefania S d'Amora Marta M Camisasca Adalberto A Diaspro Alberto A Giordani Silvia S

Beilstein journal of nanotechnology 20170907

Multishell fullerenes, known as carbon nano-onions (CNOs), have emerged as a platform for bioimaging because of their cell-penetration properties and minimal systemic toxicity. Here, we describe the covalent functionalization of CNOs with a π-extended distyryl-substituted boron dipyrromethene (BODIPY) dye with on/off modulated fluorescence emission activated by an acidic environment. The switching properties are linked to the photoinduced electron transfer (PET) characteristics of the dimethylam ...[more]

PMID: 29046835

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