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Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis.


ABSTRACT: The relationship between hypothyroidism and primary open angle glaucoma (POAG) has attracted intense interest recently, but the reported results have been controversial. This meta-analysis was carried out to determine the association between hypothyroidism and POAG.The literature was identified from three databases (Web of Science, Embase, and PubMed). The meta-analyses were performed using random-effects models, with results reported as adjusted odds ratios (ORs) with 95% confidence intervals (CI 95%).A total of 11 studies meeting the inclusion criteria were included in the final meta-analysis. The pooled OR based on 11 risk estimates showed a statistically significant increased risk of POAG prevalence among individuals with hypothyroidism (OR = 1.64, 95% CI = 1.27-2.13). Substantial heterogeneity among these studies was detected (P < 0.001; I2 = 83.2%). Sub-group analysis revealed that the cohort studies and case-control studies showed a significant association between hypothyroidism and POAG, which was not observed in cross-sectional studies. There was no significant publication bias in this study.The findings of this meta-analysis indicate that individuals with hypothyroidism have an increased risk of developing POAG.

SUBMITTER: Wang S 

PROVIDER: S-EPMC5656411 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis.

Wang Shiming S   Liu Yue Y   Zheng Guangying G  

PloS one 20171025 10


<h4>Purpose</h4>The relationship between hypothyroidism and primary open angle glaucoma (POAG) has attracted intense interest recently, but the reported results have been controversial. This meta-analysis was carried out to determine the association between hypothyroidism and POAG.<h4>Methods</h4>The literature was identified from three databases (Web of Science, Embase, and PubMed). The meta-analyses were performed using random-effects models, with results reported as adjusted odds ratios (ORs)  ...[more]

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