Ontology highlight
ABSTRACT:
SUBMITTER: Beute J
PROVIDER: S-EPMC5821178 | biostudies-other | 2018 Jan
REPOSITORIES: biostudies-other
Beute Jan J Lukkes Melanie M Koekoek Ewout P EP Nastiti Hedwika H Ganesh Keerthana K de Bruijn Marjolein Jw MJ Hockman Steve S van Nimwegen Menno M Braunstahl Gert-Jan GJ Boon Louis L Lambrecht Bart N BN Manganiello Vince C VC Hendriks Rudi W RW KleinJan Alex A
JCI insight 20180125 2
Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans. Case reports showed that enoximone, which is a smooth muscle relaxant that inhibits PDE3, is beneficial and lifesaving in status asthmaticus and is well tolerated. However, clinical observations also show ...[more]