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Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

ABSTRACT: Echo planar imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determined. We show here that blip-reversed echo planar imaging can also be used to correct for susceptibility and B0 inhomogeneity effects that would otherwise produce image-domain distortion in the heart.Previously acquired blip-reversed cardiac 3D-Spectral-Spatial echo planar imaging volumetric timecourses of hyperpolarized [1-13 C]pyruvate were distortion corrected by a deformation field estimated by reconstructing signal-to-noise ratio (SNR)-weighted progressively subsampled temporally summed images of each metabolite.Reconstructing blip-reversed data as proposed produced volumetric timecourses that overlaid with proton reference images more consistently than without such corrections.The method proposed may form an attractive method to correct for image-domain distortions in hyperpolarized echo planar imaging experiments. Magn Reson Med 79:2135-2141, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

SUBMITTER: Miller JJ

PROVIDER: S-EPMC5836862 | biostudies-other | 2018 Apr

REPOSITORIES: biostudies-other

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Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

Miller Jack J JJ Lau Angus Z AZ Tyler Damian J DJ

Magnetic resonance in medicine 20170719 4

<h4>Purpose</h4>Echo planar imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determined. We show here that blip-reversed echo planar imaging can also be used to correct for susceptibility and B<sub>0</sub> inhomogeneity effects that would otherwise produce image-domain distortion in the heart.<h4>Methods</h4>Previously acqu ...[more]

PMID: 28722201

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Project description:PurposeTo develop a purpose-built quiet echo planar imaging capability for fetal functional and diffusion scans, for which acoustic considerations often compromise efficiency and resolution as well as angular/temporal coverage.MethodsThe gradient waveforms in multiband-accelerated single-shot echo planar imaging sequences have been redesigned to minimize spectral content. This includes a sinusoidal read-out with a single fundamental frequency, a constant phase encoding gradient, overlapping smoothed CAIPIRINHA blips, and a novel strategy to merge the crushers in diffusion MRI. These changes are then tuned in conjunction with the gradient system frequency response function.ResultsMaintained image quality, SNR, and quantitative diffusion values while reducing acoustic noise up to 12 dB (A) is illustrated in two adult experiments. Fetal experiments in 10 subjects covering a range of parameters depict the adaptability and increased efficiency of quiet echo planar imaging.ConclusionPurpose-built for highly efficient multiband fetal echo planar imaging studies, the presented framework reduces acoustic noise for all echo planar imaging-based sequences. Full optimization by tuning to the gradient frequency response functions allows for a maximally time-efficient scan within safe limits. This allows ambitious in-utero studies such as functional brain imaging with high spatial/temporal resolution and diffusion scans with high angular/spatial resolution to be run in a highly efficient manner at acceptable sound levels. Magn Reson Med 79:1447-1459, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Dataset Information

Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

Publications

Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

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