Ontology highlight
ABSTRACT:
SUBMITTER: Arora K
PROVIDER: S-EPMC5841874 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Arora Kavisha K Huang Yunjie Y Mun Kyushik K Yarlagadda Sunitha S Sundaram Nambirajan N Kessler Marco M MM Hannig Gerhard G Kurtz Caroline B CB Silos-Santiago Inmaculada I Helmrath Michael M Palermo Joseph J JJ Clancy John P JP Steinbrecher Kris A KA Naren Anjaparavanda P AP
JCI insight 20171005 19
Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel function. CF manifestations of the pancreas and lung are present in the vast majority of CF patients, and 15% of CF infants are born with obstructed gut or meconium ileus. However, constipation is a significantly underreported outcome of CF disease, affecting 47% of the CF patients, ...[more]