Unknown

Dataset Information

0

Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs.


ABSTRACT: Biocompatible surfactants are of diverse pharmaceutical interest due to their ability to self-assemble into nano-particulate systems which can be used for single-step drug loading, based upon the hydrophobic-hydrophobic interaction between a hydrophobic drug and the lipophilic part of a surfactant molecule. However, surfactants are associated with cytotoxicity and hemolysis due to their amphiphilic interaction with cellular membranes. This study reports a novel membrane-compatible surfactant, synthesized from sulfanilamide and its self-micellization into niosomes. The surfactant was synthesized in a single step reaction via the introduction of an alkyl chain in the sulfanilamide moiety by conjugation with deconyl chloride. The synthesized surfactant (S-SDC) was characterized by 1H and 13C NMR, mass spectrometry and single crystal XRD. The S-SDC niosomes were explored for drug delivery with clarithromycin as a model drug. The biocompatibility of the surfactant was investigated through hemolysis and cytotoxicity. The surfactant presented a very low critical micellar concentration (CMC) of 0.04 mM and entrapped 65% of the drug which was released in a sustained manner, over 12 h, at acidic and physiological pH. The vesicles were spherical in shape with 234 ± 3.61 nm mean diameter and a narrow size distribution. Niosomes were hemocompatible and nontoxic to cellular membrane. The results suggested the sulfanilamide based surfactant can be applied as a novel and cell membrane compatible niosomal drug delivery vehicle.

SUBMITTER: Ali I 

PROVIDER: S-EPMC6116827 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

altmetric image

Publications

Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs.

Ali Imdad I   Shah Muhammad Raza MR   Yousuf Sammer S   Ahmed Shakil S   Shah Kiramat K   Javed Ibrahim I  

Toxicology research 20180613 5


Biocompatible surfactants are of diverse pharmaceutical interest due to their ability to self-assemble into nano-particulate systems which can be used for single-step drug loading, based upon the hydrophobic-hydrophobic interaction between a hydrophobic drug and the lipophilic part of a surfactant molecule. However, surfactants are associated with cytotoxicity and hemolysis due to their amphiphilic interaction with cellular membranes. This study reports a novel membrane-compatible surfactant, sy  ...[more]

Similar Datasets

| S-EPMC5457098 | biostudies-other
| S-EPMC7412056 | biostudies-literature
| S-EPMC4315539 | biostudies-literature
| S-EPMC3099414 | biostudies-literature
| S-EPMC7914313 | biostudies-literature
| S-EPMC4571016 | biostudies-literature
| S-EPMC6320896 | biostudies-other
| S-EPMC7860091 | biostudies-literature
| S-EPMC6648986 | biostudies-literature
| S-EPMC10134496 | biostudies-literature