Ontology highlight
ABSTRACT:
SUBMITTER: Ali A
PROVIDER: S-EPMC6151090 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
The Journal of infectious diseases 20180901 9
A 48-year-old woman was infected with a vpr-defective human immunodeficiency virus (HIV)-1 molecular clone. Seroconversion was markedly delayed, and without treatment she had durably suppressed viremia and normal T-cell levels. Neutralizing antibody and CD8+ T-cell immune responses against HIV-1 were unremarkable. Viral sequences confirmed the source but evolved defective nef, suggesting an unknown mechanistic link to vpr. There were subtle qualitative defects in T and B cells. To our knowledge, ...[more]